RELATIONSHIP OF APOPTOSIS AND SECONDARY NECROSIS OF LEUCOCYTES WITH ACTIVITY OF DISEASE AND CLINICAL MANIFESTATION IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS

The presence of several different autoantibodies (auto-AT) at the same time is a specific peculiarity “autoantibody profile” SLE (systemic lupus erythematosus). It known that induction auto-AT formation involves both nonspecific and antigen-specific immunoregulatory disorders. In apoptosis, primary changes in cell membrane composition or/and excretion intracellular compounds into intercellular milieu lead to an inflammatory reaction.  purpose study was highlight connection between apoptosis secondary necrosis granulocytes mononuclear (lymphocytes monocytes) with inflammation activity patients improve diagnosis basic therapy efficacy. SLE, 3.4 times higher compared healthy control. Moreover, level apoptotic monocytes 1.87 higher, 5.58 than lymphocytes 9.0 case usage Apolect technology allows differentiating various types immunological analysis degree immunocompetent cells (granulocytes, monocytes, lymphocytes) determine aggressiveness cytostatic predict development complications this disease.